Cytokines Recombinant Proteins

Mouse IL5RA Recombinant Protein (RPPB0521)

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SKU:
RPPB0521
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P21183
Research Area:
Cytokines

Description

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Product Name:Mouse IL5RA Recombinant Protein
Product Code:RPPB0521
Size:10µg
Species:Mouse
Target:IL5RA
Synonyms:Interleukin-5 receptor subunit alpha, IL-5 receptorsubunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CD125.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL5RA protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% asdetermined by SDS-PAGE.
Amino Acid Sequence:DLLNHKKFLL LPPVNFTIKA TGLAQVLLHW DPNPDQEQRH VDLEYHVKINAPQEDEYDTR KTESKCVTPL HEGFAASVRT ILKSSHTTLA SSWVSAELKA PPGSPGTSVT NLTCTTHTVVSSHTHLRPYQ VSLRCTWLVG KDAPEDTQYF LYYRFGVLTE KCQEYSRDAL NRNTACWFPRTFINSKGFEQ LAVHINGSSKRAAIKPFDQL FSPLAIDQVN PPRNVTVEIE SNSLYIQWEK PLSAFPDHCF NYELKIYNTK NGHIQKEKLI ANKFISKIDDVSTYSIQVRA AVSSPCRMPG RWGEWSQPIY VGKERKSLVE WHLEHHHHHH

Interleukin-5 receptor subunit alpha (Il5ra) regulates the development and function of eosinophils. The Il5ra protein is a therapeutic target for hypereosinophilic diseases including allergic inflammations and asthma. Oct2 enhances antibody-secreting cell differentiation via regulation of Il5ra chain expression on activated B cells.

IL5RA Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 330 amino acids (18-339a.a.) and having a molecular mass of 37.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).IL5RA is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL5RA: This is the receptor for interleukin-5. The alpha chain binds to IL5. Belongs to the type I cytokine receptor family. Type 5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, cytokineChromosomal Location of Human Ortholog: 6 E1|6 49.19 cMCellular Component: integral component of membrane; membraneMolecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activityBiological Process: cellular response to organic substance; inflammatory response to antigenic stimulus; regulation of interleukin-5 production
UniProt Protein Details:
NCBI Summary:
UniProt Code:P21183
NCBI GenInfo Identifier:6680431
NCBI Gene ID:16192
NCBI Accession:NP_032396.1
UniProt Secondary Accession:P21183
UniProt Related Accession:P21183
Molecular Weight:
NCBI Full Name:interleukin-5 receptor subunit alpha
NCBI Synonym Full Names:interleukin 5 receptor, alpha
NCBI Official Symbol:Il5ra��
NCBI Official Synonym Symbols:Il5r; CD125; CDw125��
NCBI Protein Information:interleukin-5 receptor subunit alpha
UniProt Protein Name:Interleukin-5 receptor subunit alpha
UniProt Synonym Protein Names:CD_antigen: CD125
Protein Family:Interleukin-5 receptor
UniProt Gene Name:Il5ra��
UniProt Entry Name:
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