Cytokines Recombinant Proteins

Mouse IL36A Recombinant Protein (RPPB0680)

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SKU:
RPPB0680
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9JLA2
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse IL36A Recombinant Protein
Product Code:RPPB0680
Size:20µg
Species:Mouse
Target:IL36A
Synonyms:Interleukin-36 alpha, FIL1epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6,Interleukin-1 homolog 1, IL-1H1, Il36a, Fil1e, Il1e, Il1f6, Il1h1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IL36A protein solution (1mg/ml) containing PhosphateBuffered Saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMNKEKELRAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLFCTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELGEIFITDFEMI VVH

Human IL-36a belongs to the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. IL-36a is an 18-22kDa, 158aa intracellular and secreted protein which holds no signal sequence, no prosegment and no potential from N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor.Human IL-36a (aa 6-158) shares 57-68% aa sequence homology with mouse, rabbit, equine and bovine IL-36a and 27-57% aa sequence homology with other new IL-1 family members. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.

IL36A Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 183 amino acids (1-160 a.a) andhaving a molecular mass of 20.4kDa. IL36A is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1F6: Belongs to the IL-1 family.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9JLA2
NCBI GenInfo Identifier:9506601
NCBI Gene ID:54448
NCBI Accession:NP_062323.1
UniProt Secondary Accession:Q9JLA2
UniProt Related Accession:Q9JLA2
Molecular Weight:18,015 Da
NCBI Full Name:interleukin-36 alpha
NCBI Synonym Full Names:interleukin 1 family, member 6
NCBI Official Symbol:Il1f6��
NCBI Official Synonym Symbols:Fil1; Il1f9; Il36a; IL-1H1; IL1RP2��
NCBI Protein Information:interleukin-36 alpha
UniProt Protein Name:Interleukin-36 alpha
UniProt Synonym Protein Names:FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1
Protein Family:Interleukin
UniProt Gene Name:Il36a��
UniProt Entry Name:IL36A_MOUSE
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