Cytokines Recombinant Proteins

Mouse IL36A 153 a.a. Recombinant Protein (RPPB0679)

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SKU:
RPPB0679
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9JLA2
Research Area:
Cytokines

Description

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Product Name:Mouse IL36A 153 a.a. Recombinant Protein
Product Code:RPPB0679
Size:10µg
Species:Mouse
Target:IL36A 153 a.a.
Synonyms:Interleukin 36 alpha, FIL1E, IL1F6, FIL1, IL1(EPSILON), interleukin 1 family member 6 (epsilon), MGC129552, MGC129553.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2?m filtered concentrated solution in 1xPBS, pH 7.4 and 5% trehalose.
Solubility:It is recommended to reconstitute the lyophilized IL36A 153 a.a. Mouse in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL36A 153 a.a. Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL36A 153 a.a. Mouse should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE and HPLC analyses.
Amino Acid Sequence:RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMI VVH
Biological Activity:Fully biologically active when compared to standard. The ED50 as measured by its ability to induce IL-6 secretion in NIH-3T3 mouse embryonic fibroblast cells is less than 20ng/ml, corresponding to a specific activity of 50,000IU/mg.

Murine IL-36a belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Murine IL-36a is a 160 amino acid intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Mouse to human, full length IL-36a/IL-1F6 shares 54% aa sequence homology. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.

IL36A 153 a.a. Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (8-160a.a.) and having a molecular mass of 17.0kDa.The IL36A 153 a.a. Mouse is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1F6: Belongs to the IL-1 family.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9JLA2
NCBI GenInfo Identifier:9506601
NCBI Gene ID:54448
NCBI Accession:NP_062323.1
UniProt Secondary Accession:Q9JLA2
UniProt Related Accession:Q9JLA2
Molecular Weight:18,015 Da
NCBI Full Name:interleukin-36 alpha
NCBI Synonym Full Names:interleukin 1 family, member 6
NCBI Official Symbol:Il1f6��
NCBI Official Synonym Symbols:Fil1; Il1f9; Il36a; IL-1H1; IL1RP2��
NCBI Protein Information:interleukin-36 alpha
UniProt Protein Name:Interleukin-36 alpha
UniProt Synonym Protein Names:FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1
Protein Family:Interleukin
UniProt Gene Name:Il36a��
UniProt Entry Name:IL36A_MOUSE
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