Cytokines Recombinant Proteins

Mouse IL34 Recombinant Protein (RPPB0671)

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SKU:
RPPB0671
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q8R1R4
Research Area:
Cytokines

Description

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Product Name:Mouse IL34 Recombinant Protein
Product Code:RPPB0671
Size:10µg
Species:Mouse
Target:IL34
Synonyms:Interleukin-34, IL-34, Il34.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IL34 protein solution (0.5mg/ml) in 20mM Tris-HCl buffer (pH 8.0)�and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNENLEIWTL TQDKECDLTG YLRGKLQYKN RLQYMKHYFP INYRIAVPYE GVLRVANITRLQKAHVSERE LRYLWVLVSL NATESVMDVL LEGHPSWKYL QEVQTLLENV QRSLMDVEIG PHVEAVLSLLSTPGLSLKLV RPKALLDNCF RVMELLYCSC CKQSPILKWQ DCELPRLHPH SPGSLMQCTA TNVYPLSRQTPTSLPGSPSS SHGSLP

Interleukin 34 (IL34) is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor and is a part of a group of cytokines called interleukins. IL34 increases growth or survival of immune cells known as monocytes. IL34 protein obtains its activity by binding the Colony stimulating factor 1 receptor. Interleukin 34 has also a potential part in viral infection, the adaptive immune response and bone marrow cell proliferation. Furthermore, IL34 plays an important role in innate immunity and in inflammatory processes.

IL34 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (21-235 a.a) and having a molecular mass of 26.8kDa.IL34 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine; Secreted; Cell cycle regulation; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space

Molecular Function:cytokine activity; growth factor activity; macrophage colony stimulating factor receptor binding

Biological Process: immune system process; inflammatory response; innate immune response; positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of protein amino acid phosphorylation

UniProt Code:Q8R1R4
NCBI GenInfo Identifier:81901471
NCBI Gene ID:76527
NCBI Accession:Q8R1R4.1
UniProt Secondary Accession:Q8R1R4,Q9D8F2, B2ZC71, B2ZC72,
UniProt Related Accession:Q8R1R4
Molecular Weight:26,636 Da
NCBI Full Name:Interleukin-34
NCBI Synonym Full Names:interleukin 34
NCBI Official Symbol:Il34��
NCBI Official Synonym Symbols:AI593503; 2010004A03Rik��
NCBI Protein Information:interleukin-34
UniProt Protein Name:Interleukin-34
Protein Family:Interleukin
UniProt Gene Name:Il34��
UniProt Entry Name:IL34_MOUSE
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