Cytokines Recombinant Proteins

Mouse IL31 Recombinant Protein (RPPB0658)

(No reviews yet) Write a Review
SKU:
RPPB0658
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q6EAL8
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse IL31 Recombinant Protein
Product Code:RPPB0658
Size:10µg
Species:Mouse
Target:IL31
Synonyms:Interleukin 31, IL31, IL-31.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The IL31 (1mg/ml) was lyophilized from 10mM sodium Phosphate pH-7.5.
Solubility:It is recommended to reconstitute the lyophilized IL31 in sterile 18M? -cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL31 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL31 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C

IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells.Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions, including regulating hematopoiesis & immune re

IL31 mouse recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a molecular mass of 15.7 kDa.

UniProt Protein Function:IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunityProtein type: Cytokine; Secreted, signal peptide; SecretedCellular Component: extracellular space; extracellular regionMolecular Function: cytokine activityBiological Process: immune system process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q6EAL8
NCBI GenInfo Identifier:81863672
NCBI Gene ID:76399
NCBI Accession:Q6EAL8.1
UniProt Secondary Accession:Q6EAL8
UniProt Related Accession:Q6EAL8
Molecular Weight:18,120 Da
NCBI Full Name:Interleukin-31
NCBI Synonym Full Names:interleukin 31
NCBI Official Symbol:Il31��
NCBI Official Synonym Symbols:1700013B14Rik��
NCBI Protein Information:interleukin-31; IL-31
UniProt Protein Name:Interleukin-31
UniProt Synonym Protein Names:
Protein Family:Interleukin
UniProt Gene Name:Il31��
UniProt Entry Name:IL31_MOUSE
View AllClose

0 Reviews

View AllClose

Related Products