Cytokines Recombinant Proteins

Mouse IL1RA Recombinant Protein (RPPB0472)

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SKU:
RPPB0472
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P25085
Research Area:
Cytokines

Description

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Product Name:Mouse IL1RA Recombinant Protein
Product Code:RPPB0472
Size:20µg
Species:Mouse
Target:IL1RA
Synonyms:IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IL1RA solution (1 mg/ml) contains 10% Glycerol, 20mM Tris-HCl buffer (pH 8.0) and 0.1M NaCl
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than�95.0%�as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMRPSGK RPCKMQAFRI WDTNQKTFYL RNNQLIAGYLQGPNIKLEEK IDMVPIDLHS VFLGIHGGKL CLSCAKSGDD IKLQLEEVNI TDLSKNKEEDKRFTFIRSEK GPTTSFESAA CPGWFLCTTL EADRPVSLTN TPEEPLIVTK FYFQEDQ
Biological Activity:Measured by the ability to inhibit proliferation using D10.G4.1 mouse helper T cells. ED50 for this effect is ? 60 ng/ml with Mouse IL-1 alpha.

Interleukin-1 ra is a member of the interleukin 1 cytokine family. IL1RAinhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. IL1RAand five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.

IL1RA Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (27-178 aa) and having a molecular mass of 20kDa.IL1RA is fused to a 25 amino acid His tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Vesicle; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space; cell; cytoplasm; extracellular region; vesicle

Molecular Function:interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity

Biological Process: positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; cytokine and chemokine mediated signaling pathway; response to glucocorticoid stimulus; sensory perception of pain; fever; memory; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis

UniProt Code:P25085
NCBI GenInfo Identifier:124313
NCBI Gene ID:16181
NCBI Accession:P25085.1
UniProt Secondary Accession:P25085,O70207,
UniProt Related Accession:P25085
Molecular Weight:17,996 Da
NCBI Full Name:Interleukin-1 receptor antagonist protein
NCBI Synonym Full Names:interleukin 1 receptor antagonist
NCBI Official Symbol:Il1rn��
NCBI Official Synonym Symbols:IL-1ra; F630041P17Rik��
NCBI Protein Information:interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor
UniProt Protein Name:Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names:IL1 inhibitor
Protein Family:Interleukin-1 receptor antagonist protein
UniProt Gene Name:Il1rn��
UniProt Entry Name:IL1RA_MOUSE
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