Immunology Recombinant Proteins

Mouse IL1R1/CD121a Recombinant Protein (RPES1157)

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RPES1157

Description

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Mouse IL1R1/CD121a Recombinant Protein

Mouse Interleukin-1 receptor type 1/IL-1 RI is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1? or IL1βbut not IL1ra, was identified. This Type I receptor complex appears to mediate all the known IL1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL1 signals. In addition to the membranebound form of IL1 RII, a naturallyoccurring soluble form of IL1 RII has been described. It has been suggested that the Type II receptor, either as the membranebound or as the soluble form, serves as a decoy for IL1 and inhibits IL1 action by blocking the binding of IL1 to the signaling Type I receptor complex.

Product Name:Mouse IL1R1/CD121a Recombinant Protein (RPES1157)
Product Code:RPES1157
Size:10µg
Species:Mouse
Expressed Host:Human Cells
Synonyms:Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, p80, CD121a, mIL-1R1
Accession:P13504
Sequence: Leu20-Lys338
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse Interleukin-1 receptor type 1 is produced by our Mammalian expression system and the target gene encoding Leu20-Lys338 is expressed with a Fc tag at the C-terminus.
Purity:> 90 % as determined by SDS-PAGE
Mol Mass:64.0 kDa
AP Mol Mass:85-110&140 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Research Area:
Immunology
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