Cytokines Recombinant Proteins

Mouse IL17RB Recombinant Protein (RPPB0619)

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SKU:
RPPB0619
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9Z132
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse IL17RB Recombinant Protein
Product Code:RPPB0619
Size:10µg
Species:Mouse
Target:IL17RB
Synonyms:Il17rb, Evi27, IL-17ER, IL-17Rh1, Il17br, IL17RH1, IL-17receptor B, IL-17RB, Interleukin-17 receptor B.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IL17RB protein solution (1mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPREPTIQC GSETGPSPEWMVQHTLTPGD LRDLQVELVK TSVAAEEFSI LMNISWILRA DASIRLLKAT KICVSGKNNM NSYSCVRCNYTEAFQSQTRP SGGKWTFSYV GFPVELSTLY LISAHNIPNA NMNEDSPSLS VNFTSPGCLN HVMKYKKQCTEAGSLWDPDI TACKKNEKMV EVNFTTNPLG NRYTILIQRD TTLGFSRVLE NKLMRTSVAI PVTEESEGAVVQLTPYLHTC GNDCIRREGT VVLCSETSAP IPPDDNRRML GGVEPKSCDK THTCPPCPAP ELLGGPSVFLFPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQDWLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWESNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL17RB produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 511 amino acids (18-286 a.a.) andhaving a molecular mass of 57.1kDa (Molecular size on SDS-PAGE will appear atapproximately 57-70kDa). IL17RB is expressed with an 242 amino acid hIgG-His tagat C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:R-spondin-1: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC). This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptide; Cell adhesion; Cell development/differentiationCellular Component: extracellular space; extracellular region; nucleusMolecular Function: heparin binding; protein binding; G-protein-coupled receptor binding; receptor bindingBiological Process: Wnt receptor signaling pathway; regulation of gene expression; regulation of receptor internalization; response to stimulus; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation; male meiosis; positive regulation of Wnt receptor signaling pathway
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9Z132
NCBI GenInfo Identifier:227452351
NCBI Gene ID:192199
NCBI Accession:NP_619624.2
UniProt Secondary Accession:Q9Z132,Q3V1S3
UniProt Related Accession:Q9Z132
Molecular Weight:29,332 Da
NCBI Full Name:R-spondin-1
NCBI Synonym Full Names:R-spondin homolog (Xenopus laevis)
NCBI Official Symbol:Rspo1��
NCBI Official Synonym Symbols:Rspondin; R-spondin��
NCBI Protein Information:R-spondin-1; cristin-3; mCristin-3; roof plate-specific spondin-1; thrombospondin type 1 domain containing gene Rspondin; cysteine-rich and single thrombospondin domain-containing protein 3
UniProt Protein Name:R-spondin-1
UniProt Synonym Protein Names:Cysteine-rich and single thrombospondin domain-containing protein 3; Cristin-3; mCristin-3; Roof plate-specific spondin-1
Protein Family:R-spondin
UniProt Gene Name:Rspo1��
UniProt Entry Name:RSPO1_MOUSE
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