Cytokines Recombinant Proteins

Mouse IL17A Recombinant Protein (RPPB0609)

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RPPB0609

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse IL17A Recombinant Protein
Product Code:RPPB0609
Size:10µg
Species:Mouse
Target:IL17A
Synonyms:IL17A, Ctla-8, Ctla8, IL-17, IL-17A, Il17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IL17A solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAALEHHHHH H�

Interleukin-17A or IL17A is a cytokine, that has a crucial part in chronic & anti-microbial inflammation. Mouse, rat and human share approximately 60% resemblance is the amino acid sequence. IL17A enhances mucosal & epidermal inflammation when an infection from bacteria occurs, it causes production of chemokines, influx of neutrophils & antibacterial proteins production.

IL17A Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 141 amino acids (26-158 a.a) and having a molecular mass of 16kDa.IL17A is fused to an 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function:cytokine activity

Biological Process: positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

UniProt Code:Q62386
NCBI GenInfo Identifier:2498482
NCBI Gene ID:16171
NCBI Accession:Q62386.1
UniProt Secondary Accession:Q62386,Q60971,
UniProt Related Accession:Q62386
Molecular Weight:17,490 Da
NCBI Full Name:Interleukin-17A
NCBI Synonym Full Names:interleukin 17A
NCBI Official Symbol:Il17a��
NCBI Official Synonym Symbols:Il17; Ctla8; IL-17; Ctla-8; IL-17A��
NCBI Protein Information:interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8
UniProt Protein Name:Interleukin-17A
UniProt Synonym Protein Names:Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family:Interleukin
UniProt Gene Name:Il17a��
UniProt Entry Name:IL17_MOUSE
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q62386
Research Area:
Cytokines
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