Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Product Name:
Mouse IL10RB/IL10R2 Recombinant Protein (RPES4106)
Immobilized mouse IL10RB-His at 10 µg/ml (100 ?l/well) can bind biotinylated human IL28B-His, The EC50 of biotinylated human IL28B-His is 0.13-0.31 µg/ml.
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of mouse IL10RB (NP_032375.2) (Met 1-Ser 222) was expressed, with a C-terminal polyhistidine tag.
Purity:
> 98 % as determined by SDS-PAGE
Mol Mass:
25 kDa
AP Mol Mass:
35-45 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetMouse IL10RB/IL10R2 Recombinant Protein Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor
system_update_altDatasheetHuman IL10RB/IL10R2 Recombinant Protein Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member
system_update_altDatasheetHuman IL10RB/IL10R2 Recombinant Protein IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is
system_update_altDatasheetRat IL10RB/IL10R2 Recombinant Protein Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor s
system_update_altDatasheetHuman IL10RB/IL10R2 Recombinant Protein Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor
