Growth Factors & Cytokines Recombinant Proteins
Mouse IL beta/IL1B Recombinant Protein (RPES4658)
- SKU:
- RPES4658
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Growth Factors & Cytokines
Description
Mouse IL beta/IL1B Recombinant Protein
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Mouse IL beta/IL1B Recombinant Protein (RPES4658) |
| Product Code: | RPES4658 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | E.coli |
| Synonyms: | Il-1b,IL-1beta |
| Accession: | P10749 |
| Sequence: | Val 118-Ser 269 |
| Activity: | 1. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 6-30 ng/mL..2. Measured by its ability to bind human IL1R1 in a functional ELISA.3. Measured by its ability to bind mouse IL1R1 in a functional ELISA. |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the mature form of mouse IL1? (P10749) (Val 118-Ser 269) was expressed, with an initial Met at the C-terminus. |
| Purity: | > 97 % as determined by SDS-PAGE |
| Mol Mass: | 17.5 kDa |
| AP Mol Mass: | 19 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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