Cytokines Recombinant Proteins
Mouse IL 3 Recombinant Protein (RPPB0498)
- SKU:
- RPPB0498
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P01586
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL 3 Recombinant Protein |
| Product Code: | RPPB0498 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL 3 |
| Synonyms: | MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin-3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Asp-Thr-His-Arg |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of murine M-NFS-60 cells is < 0.05 ng/ml, corresponding to a Specific Activity of 20,000,000IU/mg. |
Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils.
Interleukin-3 mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids and having a molecular mass of 15100 Dalton. The IL-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Oncoprotein Cellular Component: extracellular space; extracellular region Molecular Function:interleukin-3 receptor binding; growth factor activity; cytokine activity Biological Process: myeloid cell apoptosis; regulation of protein amino acid dephosphorylation; negative regulation of autophagy; cytokine and chemokine mediated signaling pathway; response to hormone stimulus; positive regulation of JNK cascade; positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; negative regulation of mast cell apoptosis; regulation of glycolysis; positive regulation of cell proliferation; response to hypoxia; hemopoiesis; immune response; regulation of cell growth; positive regulation of protein amino acid phosphorylation; positive regulation of myeloid leukocyte differentiation; negative regulation of apoptosis |
| UniProt Code: | P01586 |
| NCBI GenInfo Identifier: | 124333 |
| NCBI Gene ID: | 16187 |
| NCBI Accession: | P01586.1 |
| UniProt Related Accession: | P01586 |
| Molecular Weight: | 18,540 Da |
| NCBI Full Name: | Interleukin-3 |
| NCBI Synonym Full Names: | interleukin 3 |
| NCBI Official Symbol: | Il3�� |
| NCBI Official Synonym Symbols: | BPA; PSF; HCGF; Il-3; MCGF; Csfmu�� |
| NCBI Protein Information: | interleukin-3; mast cell growth factor; P-cell-stimulating factor; hematopoietic growth factor; multipotential colony-stimulating factor |
| UniProt Protein Name: | Interleukin-3 |
| UniProt Synonym Protein Names: | Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il3�� |
| UniProt Entry Name: | IL3_MOUSE |
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