Cytokines Recombinant Proteins

Mouse IL 22 Recombinant Protein (RPPB0639)

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SKU:
RPPB0639
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9JJY9
Research Area:
Cytokines

Description

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Product Name:Mouse IL 22 Recombinant Protein
Product Code:RPPB0639
Size:10µg
Species:Mouse
Target:IL 22
Synonyms:IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from 1X PBS.
Solubility:It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL22 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Val-Asn
Biological Activity:The ED50 as determined by its ability to induce IL-10 secretion in Colo205 cells is less than 0.5ng/ml, corresponding to a Specific Activity of 2,000,000IU/mg.

Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acids signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10, respectively. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses.

Interleukin-22 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 147 amino acids and having a molecular mass of 16.7 kDa. The Murine IL-22 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function:protein binding; cytokine activity

Biological Process: regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter

UniProt Code:Q9JJY9
NCBI GenInfo Identifier:17366895
NCBI Gene ID:50929
NCBI Accession:Q9JJY9.1
UniProt Secondary Accession:Q9JJY9,Q14BB3,
UniProt Related Accession:Q9JJY9
Molecular Weight:20,106 Da
NCBI Full Name:Interleukin-22
NCBI Synonym Full Names:interleukin 22
NCBI Official Symbol:Il22��
NCBI Official Synonym Symbols:IL-22; Iltif; IL-22a; ILTIFa��
NCBI Protein Information:interleukin-22; ILTIF alpha; IL-TIF alpha; interleukin-22a; IL-10-related T-cell-derived-inducible factor; interleukin 10-related T cell-derived inducible factor
UniProt Protein Name:Interleukin-22
UniProt Synonym Protein Names:IL-10-related T-cell-derived-inducible factor; IL-TIF; IL-TIF alpha; Interleukin-22a; IL-22a
UniProt Gene Name:Il22��
UniProt Entry Name:IL22_MOUSE
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