Cytokines Recombinant Proteins

Mouse IL-22 Antagonist Recombinant Protein (RPPB0642)

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SKU:
RPPB0642
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9JJY9
Research Area:
Cytokines

Description

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Product Name:Mouse IL-22 Antagonist Recombinant Protein
Product Code:RPPB0642
Size:10µg
Species:Mouse
Target:IL-22 Antagonist
Synonyms:IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:IL-22�Antagonist Mouse�is lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3.
Solubility:It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-22 Mouse Antagonist�although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL22�Antagonist�should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Gel filtration chromatography under non-denaturing conditions.(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Pro-Val-Asn
Biological Activity:IL-22 E117A mutant is capable of full inhibition of STAT3 phosphorylation induced by mouse interleukin 22 in HepG cells. Its affinity toward immobilized mIL-22 receptor a1 extracellular domain (mIL-22 Ra1-ECD) or IL-22 binding protein is similar to the non-mutated mouse interleukin 22. Mouse IL-22 antagonist (E117A) has very low agonistic activity in this bioassay.

IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.

Interleukin-22 Antagonist Mouse Recombinant produced in E.Coli is a single, non-glycosylated homodimeric polypeptide chain containing 147 amino acids and having a total molecular mass of 16.7 KDa. The Mouse IL-22 Antagonist is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function:protein binding; cytokine activity

Biological Process: regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter

UniProt Code:Q9JJY9
NCBI GenInfo Identifier:17366895
NCBI Gene ID:50929
NCBI Accession:Q9JJY9.1
UniProt Secondary Accession:Q9JJY9,Q14BB3,
UniProt Related Accession:Q9JJY9
Molecular Weight:20,106 Da
NCBI Full Name:Interleukin-22
NCBI Synonym Full Names:interleukin 22
NCBI Official Symbol:Il22��
NCBI Official Synonym Symbols:IL-22; Iltif; IL-22a; ILTIFa��
NCBI Protein Information:interleukin-22; ILTIF alpha; IL-TIF alpha; interleukin-22a; IL-10-related T-cell-derived-inducible factor; interleukin 10-related T cell-derived inducible factor
UniProt Protein Name:Interleukin-22
UniProt Synonym Protein Names:IL-10-related T-cell-derived-inducible factor; IL-TIF; IL-TIF alpha; Interleukin-22a; IL-22a
UniProt Gene Name:Il22��
UniProt Entry Name:IL22_MOUSE
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