Cytokines Recombinant Proteins

Mouse IL 1RA Recombinant Protein (RPPB0470)

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SKU:
RPPB0470
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P25085
Research Area:
Cytokines

Description

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Product Name:Mouse IL 1RA Recombinant Protein
Product Code:RPPB0470
Size:20µg
Species:Mouse
Target:IL 1RA
Synonyms:IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3.
Solubility:It is recommended to reconstitute the lyophilized Interleukin-1ra in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin 1ra although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-1ra should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by Gel Filtration.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly
Biological Activity:The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1.

Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1ra is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Vesicle; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space; cell; cytoplasm; extracellular region; vesicle

Molecular Function:interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity

Biological Process: positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; cytokine and chemokine mediated signaling pathway; response to glucocorticoid stimulus; sensory perception of pain; fever; memory; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis

UniProt Code:P25085
NCBI GenInfo Identifier:124313
NCBI Gene ID:16181
NCBI Accession:P25085.1
UniProt Secondary Accession:P25085,O70207,
UniProt Related Accession:P25085
Molecular Weight:17,996 Da
NCBI Full Name:Interleukin-1 receptor antagonist protein
NCBI Synonym Full Names:interleukin 1 receptor antagonist
NCBI Official Symbol:Il1rn��
NCBI Official Synonym Symbols:IL-1ra; F630041P17Rik��
NCBI Protein Information:interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor
UniProt Protein Name:Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names:IL1 inhibitor
Protein Family:Interleukin-1 receptor antagonist protein
UniProt Gene Name:Il1rn��
UniProt Entry Name:IL1RA_MOUSE
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