](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/12943/16995/mouse-il-17a-monoclonal-antibody-fitc-conjugated-tc11-18h10.1agel2038__99027__29980.1706270200.jpg?c=1?imbypass=on "Mouse IL-17A Monoclonal Antibody (FITC Conjugated) [TC11-18H10.1](AGEL2038)")
Description
| Antibody Name: | Mouse IL-17A Monoclonal Antibody (FITC Conjugated) |
| Antibody Code: | AGEL2038 |
| Size: | 50µg |
| Clone: | TC11-18H10.1 |
| Synonyms: | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8 |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Applications: | FC |
| Concentration: | 1mg/mL |
| Isotype: | IgG2a,k |
| Conjugation: | FITC |
| Applications: | FC |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Gene ID: | 16171 |
| Uniprot: | Q62386 |
| Background: | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
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