Cytokines Recombinant Proteins
Mouse IL 11 Recombinant Protein (RPPB0562)
- SKU:
- RPPB0562
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P47873
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL 11 Recombinant Protein |
| Product Code: | RPPB0562 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL 11 |
| Synonyms: | AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Il11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a 0.2�m filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 11 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL11 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of the proliferation of murine T11 was found to be less than 2.0 ng/ml, corresponding to a specific activity of 500,000IU/mg. |
IL11 is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). IL-11 is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
Interleukin-11 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.1kDa. The Mouse IL-11 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily. |
| UniProt Protein Details: | Protein type:Cytokine; Cell cycle regulation; Secreted, signal peptide; Motility/polarity/chemotaxis Cellular Component: extracellular space; cytoplasm; extracellular region Molecular Function:growth factor activity; cytokine activity; interleukin-11 receptor binding Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation |
| UniProt Code: | P47873 |
| NCBI GenInfo Identifier: | 1352447 |
| NCBI Gene ID: | 16156 |
| NCBI Accession: | P47873.1 |
| UniProt Related Accession: | P47873 |
| Molecular Weight: | 21,522 Da |
| NCBI Full Name: | Interleukin-11 |
| NCBI Synonym Full Names: | interleukin 11 |
| NCBI Official Symbol: | Il11�� |
| NCBI Official Synonym Symbols: | IL-11�� |
| NCBI Protein Information: | interleukin-11 |
| UniProt Protein Name: | Interleukin-11 |
| UniProt Gene Name: | Il11�� |
| UniProt Entry Name: | IL11_MOUSE |
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