Growth Factors & Cytokines Recombinant Proteins

Mouse IGF1(Long-R3-IGF1) Recombinant Protein (RPES1494)

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SKU:
RPES1494
Product Type:
Recombinant Protein
Species:
Mouse
Research Area:
Growth Factors & Cytokines

Description

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Mouse IGF1(Long-R3-IGF1) Recombinant Protein

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.

Product Name:Mouse IGF1(Long-R3-IGF1) Recombinant Protein (RPES1494)
Product Code:RPES1494
Size:10µg
Species:Mouse
Expressed Host:E.coli
Synonyms:IGF1, IGF-1, insulin-like growth factor 1, Insulin-like growth factor I,Somatomedin C, somatomedin-C
Accession:P05017
Sequence:Gly49-Ala118
Fusion tag:C-His
Activity:Measured in a serum-free cell proliferation assay using MCF?7 human breast cancer cells.  The ED50 for this effect is 842 ng/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse IGF1 is produced by our E.coli expression system and the target gene encoding Gly49-Ala118 is expressed with a 6His tag at the C-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:10.2 kDa
AP Mol Mass:12 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM NaAc, pH 4.5.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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