Cytokines Recombinant Proteins

Mouse IFNAR1 Recombinant Protein (RPPB0392)

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SKU:
RPPB0392
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P33896
Research Area:
Cytokines

Description

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Product Name:Mouse IFNAR1 Recombinant Protein
Product Code:RPPB0392
Size:10µg
Species:Mouse
Target:IFNAR1
Synonyms:IFN-R-1, IFN-alpha/beta receptor 1, Type I interferon receptor 1, Ifar, Ifnar, Infar CD118 and Ifnar1.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IFNAR1 protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ENLKPPENID VYIIDDNYTL KWSSHGESMG SVTFSAEYRT KDEAKWLKVP ECQHTTTTKC EFSLLDTNVY IKTQFRVRAE EGNSTSSWNE VDPFIPFYTA HMSPPEVRLE AEDKAILVHI SPPGQDGNMW ALEKPSFSYT IRIWQKSSSD KKTINSTYYV EKIPELLPET TYCLEVKAIH PSLKKHSNYS TVQCISTTVA NKMPVPGNLQ VDAQGKSYVL KWDYIASADV LFRAQWLPGY SKSSSGSRSD KWKPIPTCAN VQTTHCVFSQ DTVYTGTFFL HVQASEGNHT SFWSEEKFID SQKHILPPPP VITVTAMSDT LLVYVNCQDS TCDGLNYEII FWENTSNTKI SMEKDGPEFT LKNLQPLTVY CVQARVLFRA LLNKTSNFSE KLCEKTRPGS FSTLEHHHHH H

Interferon Alpha And Beta Receptor, alsoknown IFNAR1, belongs to the class II cytokine receptor family. IFNAR1protein forms one of the two chains of a receptor for interferons alpha as wellas beta. IFNAR1 binds and activates the receptor which stimulates Janus proteinkinases, which in turn phosphorylate some proteins, including STAT1 & STAT2.Furthermore, IFNAR1 also functions as an antiviral factor.

IFNAR1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids (27-429a.a) and having a molecular mass of 46.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).IFNAR1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. Protein type: Membrane protein, integral; Receptor, cytokineChromosomal Location of Human Ortholog: 16 C3.3|16 52.98 cMCellular Component: integral to plasma membraneMolecular Function: interferon receptor activity; interferon-alpha/beta binding; interferon-alpha/beta receptor activityBiological Process: defense response to virus; interferon type I biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; T cell activation
UniProt Protein Details:
NCBI Summary:
UniProt Code:P33896
NCBI GenInfo Identifier:160358843
NCBI Gene ID:15975
NCBI Accession:NP_034638.2
UniProt Secondary Accession:P33896,Q80UJ3
UniProt Related Accession:P33896
Molecular Weight:65,796 Da
NCBI Full Name:interferon alpha/beta receptor 1
NCBI Synonym Full Names:interferon (alpha and beta) receptor 1
NCBI Official Symbol:Ifnar1��
NCBI Official Synonym Symbols:Ifar; Ifrc; CD118; Ifnar; Infar��
NCBI Protein Information:interferon alpha/beta receptor 1
UniProt Protein Name:Interferon alpha/beta receptor 1
UniProt Synonym Protein Names:Type I interferon receptor 1
Protein Family:Interferon alpha/beta receptor
UniProt Gene Name:Ifnar1��
UniProt Entry Name:
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