Chemokines Recombinant Proteins

Mouse I TAC Recombinant Protein (RPPB1177)

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RPPB1177

Description

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Product Name:Mouse I TAC Recombinant Protein
Product Code:RPPB1177
Size:20µg
Species:Mouse
Target:I TAC
Synonyms:C-X-C motif chemokine 11, I-TAC, Small-inducible cytokine B11, Cxcl11, Scyb11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:I TAC protein was lyophilized from a 0.2 �m filtered concentrated solution in 10 mM Sodium Citrate, pH 4.0, with 600 mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized I TAC in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized I TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution I TAC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Amino Acid Sequence:FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM
Biological Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100 ng/ml corresponding to a specific activity of 10,000-100,000 IU/mg.

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokinen family.� I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TACchemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells.The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

I TAC Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.

UniProt Protein Function:CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Cellular Component: extracellular space; extracellular region

Molecular Function:CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; chemotaxis; inflammatory response; regulation of cell proliferation

UniProt Code:Q9JHH5
NCBI GenInfo Identifier:13124561
NCBI Gene ID:56066
NCBI Accession:Q9JHH5.1
UniProt Related Accession:Q9JHH5
Molecular Weight:11,266 Da
NCBI Full Name:C-X-C motif chemokine 11
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 11
NCBI Official Symbol:Cxcl11��
NCBI Official Synonym Symbols:Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1��
NCBI Protein Information:C-X-C motif chemokine 11; small-inducible cytokine B11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11
UniProt Protein Name:C-X-C motif chemokine 11
UniProt Synonym Protein Names:Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
UniProt Gene Name:Cxcl11��
UniProt Entry Name:CXL11_MOUSE
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9JHH5
Research Area:
Chemokines
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