Mouse HVEM/TNFRSF14 Recombinant Protein (RPES4617)
- SKU:
- RPES4617
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse HVEM/TNFRSF14 Recombinant Protein
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.
| Product Name: | Mouse HVEM/TNFRSF14 Recombinant Protein (RPES4617) |
| Product Code: | RPES4617 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Tnfrsf14, Herpesvirus entry mediator,HVEM, TR2,TNF receptor-like molecule,ATAR,another TRAF-associated receptor,Tumor necrosis factor receptor superfamily member 14,Atar,HveA |
| Accession: | NP_849262.1 |
| Sequence: | Gln39-Val207 |
| Fusion tag: | C-Fc |
| Activity: | Immobilized Mouse HVEM-Fc at 6µg/ml(100 ?l/well) can bind Human BTLA-His(Cat: PKSH033758). The ED50 of Mouse HVEM-Fc is 1.17ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Herpesvirus Entry Mediator is produced by our Mammalian expression system and the target gene encoding Gln39-Val207 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 45.6 kDa |
| AP Mol Mass: | 50&60kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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