Enzymes Recombinant Proteins

Mouse HDAC8 Recombinant Protein (RPPB1802)

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SKU:
RPPB1802
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q8VH37
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse HDAC8 Recombinant Protein
Product Code:RPPB1802
Size:5µg
Species:Mouse
Target:HDAC8
Synonyms:Histone deacetylase 8, HD8, Hdac8.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:HDAC8 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MEMPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVVHHH HHH

Histone deacetylase 8 (HDAC8) is a member of the class 1 of the histone deacetylase/acuc/apha family. HDAC8 is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a key role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation modifies chromosome structure and affects transcription factor access to DNA.

HDAC8 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 383 amino acids (1-377 a.a.) and having a molecular mass of 42.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).HDAC8 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. � � � � � � � � � � � � � � � � � � � �

UniProt Protein Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8VH37
NCBI GenInfo Identifier:29839376
NCBI Gene ID:70315
NCBI Accession:Q8VH37.2
UniProt Secondary Accession:Q8VH37,Q3V270, Q9D0K6
UniProt Related Accession:Q8VH37
Molecular Weight:28,122 Da
NCBI Full Name:Histone deacetylase 8
NCBI Synonym Full Names:histone deacetylase 8
NCBI Official Symbol:Hdac8��
NCBI Official Synonym Symbols:2610007D20Rik��
NCBI Protein Information:histone deacetylase 8
UniProt Protein Name:Histone deacetylase 8
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:Hdac8��
UniProt Entry Name:
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