Chemokines Recombinant Proteins

Mouse GRO b Recombinant Protein (RPPB1148)

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SKU:
RPPB1148
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P10889
Research Area:
Chemokines

Description

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Product Name:Mouse GRO b Recombinant Protein
Product Code:RPPB1148
Size:20µg
Species:Mouse
Target:GRO b
Synonyms:Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized GRO-beta Mouse in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN
Biological Activity:The Biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 105-106units/mg.

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.

GRO-Beta Mouse Recombinant also caled mouse MIP-2 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7849 Dalton. The CXCL2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P10889
NCBI GenInfo Identifier:127100
NCBI Gene ID:20310
NCBI Accession:P10889.2
UniProt Secondary Accession:P10889
UniProt Related Accession:P10889
Molecular Weight:10,621 Da
NCBI Full Name:C-X-C motif chemokine 2
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 2
NCBI Official Symbol:Cxcl2��
NCBI Official Synonym Symbols:GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a��
NCBI Protein Information:C-X-C motif chemokine 2; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2
UniProt Protein Name:C-X-C motif chemokine 2
UniProt Synonym Protein Names:Macrophage inflammatory protein 2; MIP2
Protein Family:C-X-C motif chemokine
UniProt Gene Name:Cxcl2��
UniProt Entry Name:CXCL2_MOUSE
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