Neurotrophins Recombinant Proteins
Mouse GMFB Recombinant Protein (RPPB0364)
- SKU:
- RPPB0364
Description
| Product Name: | Mouse GMFB Recombinant Protein |
| Product Code: | RPPB0364 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | GMFB |
| Synonyms: | Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF, C79176, AI851627, D14Ertd630e, 3110001H22Rik, 3110001O16Rik. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The GMF-beta protein was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized GMFB in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GMF-B although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GMF-beta should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | SESLVVCDVA EDLVEKLRKF RFRKETHNAA IIMKIDKDER LVVLDEELEGVSPDELKDEL PERQPRFIVY SYKYQHDDGR VSYPLCFIFS SPVGCKPEQQMMYAGSKNKL VQTAELTKVF EIRNTEDLTE EWLREKLGFF H |
GMFB is part of the GMF subfamily of the larger actin-binding protein ADF family. GMFB is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
Glia Maturation Factor-Beta (GMF-Beta) Mouse Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 141 amino acids and having a total molecular mass of 16.6kDa. GMF-Beta, Mouse Recombinant is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMF-beta: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Belongs to the actin-binding proteins ADF family. GMF subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding; Inhibitor Cellular Component: intracellular Molecular Function:growth factor activity; actin binding Biological Process: locomotory behavior; learning |
| UniProt Code: | Q9CQI3 |
| NCBI GenInfo Identifier: | 188528613 |
| NCBI Gene ID: | 63985 |
| NCBI Accession: | NP_071306.2 |
| UniProt Secondary Accession: | Q9CQI3,Q3UQX5, Q9ERL8, |
| UniProt Related Accession: | Q9CQI3 |
| Molecular Weight: | 16,723 Da |
| NCBI Full Name: | glia maturation factor beta |
| NCBI Synonym Full Names: | glia maturation factor, beta |
| NCBI Official Symbol: | Gmfb�� |
| NCBI Official Synonym Symbols: | C79176; AI851627; D14Ertd630e; 3110001H22Rik; 3110001O16Rik�� |
| NCBI Protein Information: | glia maturation factor beta |
| UniProt Protein Name: | Glia maturation factor beta |
| Protein Family: | Glia maturation factor |
| UniProt Gene Name: | Gmfb�� |
| UniProt Entry Name: | GMFB_MOUSE |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Mouse |
Uniprot: |
Q9CQI3 |
Research Area: |
Neurotrophins |
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