Growth Factors & Cytokines Recombinant Proteins
Mouse GM CSF Recombinant Protein (RPPB0357)
- SKU:
- RPPB0357
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P01587
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse GM CSF Recombinant Protein |
| Product Code: | RPPB0357 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | GM CSF |
| Synonyms: | CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, CSF2, GMCSF |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | GM-CSF Mouse was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 20mM AcOH (acetic Acid) not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GM-CSF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Thr-Arg |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of the proliferation of murine FDC-P1 cell line is < 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 IU/mg. |
GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Granulocyte Macrophage Colony Stimulating Factor Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14285.35 Dalton.GM-CSF Mouse is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Molecular Function:growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication; regulation of cell proliferation |
| UniProt Code: | P01587 |
| NCBI GenInfo Identifier: | 117562 |
| NCBI Gene ID: | 12981 |
| NCBI Accession: | P01587.1 |
| UniProt Related Accession: | P01587 |
| Molecular Weight: | 16,091 Da |
| NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor |
| NCBI Synonym Full Names: | colony stimulating factor 2 (granulocyte-macrophage) |
| NCBI Official Symbol: | Csf2�� |
| NCBI Official Synonym Symbols: | Csfgm; GMCSF; Gm-CSf; MGI-IGM�� |
| NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor; CSF; put. GM-CSF; granulocyte-macrophage colony stimulating factor 2 |
| UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Synonym Protein Names: | Colony-stimulating factor; CSF |
| Protein Family: | Granulocyte-macrophage colony-stimulating factor |
| UniProt Gene Name: | Csf2�� |
| UniProt Entry Name: | CSF2_MOUSE |
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