Enzymes Recombinant Proteins

Mouse GLRX Recombinant Protein (RPPB1700)

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SKU:
RPPB1700
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9QUH0
Research Area:
Enzymes

Description

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Product Name:Mouse GLRX Recombinant Protein
Product Code:RPPB1700
Size:20µg
Species:Mouse
Target:GLRX
Synonyms:Glutaredoxin-1, Thioltransferase-1, TTase-1, Glrx, Glrx1, Grx, Grx1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:GLRX protein solution (0.5mg/ml) containing 20mM MES (pH5.0), 20% Glycerol and �0.1M NaCl.�
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAQEFVN CKIQSGKVVV FIKPTCPYCR KTQEILSQLP FKQGLLEFVD ITATNNTSAI QDYLQQLTGA RTVPRVFIGK DCIGGCSDLI SMQQTGELMT RLKQIGALQL

GLRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GLRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.

GLRX Mouse �Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-107 a.a) and having a molecular mass of 14.3kDa. GLRX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family.
UniProt Protein Details:

Protein type:Oxidoreductase

Chromosomal Location of Human Ortholog: 13 C1|13 40.95 cM

Cellular Component: cell soma; cytoplasm; cytosol; dendrite; mitochondrial intermembrane space; mitochondrion; nucleus

Molecular Function:glutathione disulfide oxidoreductase activity; protein N-terminus binding; protein-disulfide reductase (glutathione) activity

Biological Process: positive regulation of exocytosis; positive regulation of insulin secretion; positive regulation of membrane potential

UniProt Code:Q9QUH0
NCBI GenInfo Identifier:31981458
NCBI Gene ID:93692
NCBI Accession:NP_444338.2
UniProt Related Accession:Q9QUH0
Molecular Weight:11,871 Da
NCBI Full Name:glutaredoxin-1
NCBI Synonym Full Names:glutaredoxin
NCBI Official Symbol:Glrx��
NCBI Official Synonym Symbols:Grx1; Glrx1; TTase; C86710; D13Wsu156e��
NCBI Protein Information:glutaredoxin-1
UniProt Protein Name:Glutaredoxin-1
UniProt Synonym Protein Names:Thioltransferase-1; TTase-1
Protein Family:Glutaredoxin
UniProt Gene Name:Glrx��
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