Description
| Product Name: | Mouse GLRX Recombinant Protein |
| Product Code: | RPPB1700 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | GLRX |
| Synonyms: | Glutaredoxin-1, Thioltransferase-1, TTase-1, Glrx, Glrx1, Grx, Grx1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | GLRX protein solution (0.5mg/ml) containing 20mM MES (pH5.0), 20% Glycerol and �0.1M NaCl.� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAQEFVN CKIQSGKVVV FIKPTCPYCR KTQEILSQLP FKQGLLEFVD ITATNNTSAI QDYLQQLTGA RTVPRVFIGK DCIGGCSDLI SMQQTGELMT RLKQIGALQL |
GLRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GLRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.
GLRX Mouse �Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-107 a.a) and having a molecular mass of 14.3kDa. GLRX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 13 C1|13 40.95 cM Cellular Component: cell soma; cytoplasm; cytosol; dendrite; mitochondrial intermembrane space; mitochondrion; nucleus Molecular Function:glutathione disulfide oxidoreductase activity; protein N-terminus binding; protein-disulfide reductase (glutathione) activity Biological Process: positive regulation of exocytosis; positive regulation of insulin secretion; positive regulation of membrane potential |
| UniProt Code: | Q9QUH0 |
| NCBI GenInfo Identifier: | 31981458 |
| NCBI Gene ID: | 93692 |
| NCBI Accession: | NP_444338.2 |
| UniProt Related Accession: | Q9QUH0 |
| Molecular Weight: | 11,871 Da |
| NCBI Full Name: | glutaredoxin-1 |
| NCBI Synonym Full Names: | glutaredoxin |
| NCBI Official Symbol: | Glrx�� |
| NCBI Official Synonym Symbols: | Grx1; Glrx1; TTase; C86710; D13Wsu156e�� |
| NCBI Protein Information: | glutaredoxin-1 |
| UniProt Protein Name: | Glutaredoxin-1 |
| UniProt Synonym Protein Names: | Thioltransferase-1; TTase-1 |
| Protein Family: | Glutaredoxin |
| UniProt Gene Name: | Glrx�� |
