Mouse GDF11/BMP-11 Recombinant Protein (His tag)
- SKU:
- RPES5745
Description
| Product Name: | Mouse GDF11/BMP-11 Recombinant Protein (His tag) |
| Product Code: | RPES5745 |
| Size: | 20µg |
| Species: | Mouse |
| Expression Host: | E.coli |
| Synonyms: | Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11 |
| Mol Mass: | 27.28 kDa |
| AP Mol Mass: | 35 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Thr 136-Asn 384 |
| Accession: | Q9Z1W4 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Growth Differentiation Factor 11 (GDF-11), also known as BMP-11, is a member of the TGF-beta superfamily and is highly related to GDF-8. GDF-11 encodes a 407 amino acid (aa) prepropeptide which contains a signal sequence for secretion and an RXXR proteolytic processing site to yield a 109 aa residue carboxy-terminal mature protein. Mature GDF-11 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members, however, like the TGF-beta s, Activins and GDF-8, GDF-11 also contains one extra pair of cysteine residues. At the amino acid sequence level, mature human, mouse, rat and chicken GDF-11 are 99-100% identical. As detected by in situ hybridization, GDF-11 is expressed in diverse regions of the mouse embryo: tailbud, somitic precursors, limbs, mandibular and branchial arches, dorsal neural tube, odontoblasts, nasal epithelium, and particular regions of the brain. Targeted deletion of GDF-11, in mice, results in a spectrum of abnormalities including palatal malformation, vertebral defects, elongated trunks with a reduced or absent tail, missing or malformed kidneys, and an increased number of neurons in the olfactory epithelium. GDF-11 signals through the Activin type II receptors and induces phosphorylation of Smad2 to mediate axial patterning. Systemic GDF-11 levels decline with age and administration of higher levels of GDF-11 can reverse age-related cardiac hypertrophy. In addition, systemic administration of recombinant GDF-11 protein restores genomic integrity and health of muscle stem cells, neurovasculature and enhances neurogenesis. |
Related Products
Human BMP-7 Recombinant Protein (His tag)
OverviewProduct Name:Human BMP-7 Recombinant Protein (His tag)Product Code:RPES5432Size:20µgSpecies:HumanExpres
Mouse BMP-4 Recombinant Protein (N-His) (active)
OverviewProduct Name:Mouse BMP-4 Recombinant Protein (N-His) (active)Product Code:RPES6714Size:20µgSpecies:Mouse
Mouse FABP5 Recombinant Protein (His tag)
OverviewProduct Name:Mouse FABP5 Recombinant Protein (His tag)Product Code:RPES5746Size:20µgSpecies:MouseExpres
Mouse ANGPTL4 Recombinant Protein (His tag)
OverviewProduct Name:Mouse ANGPTL4 Recombinant Protein (His tag)Product Code:RPES6117Size:20µgSpecies:MouseExpr
Mouse TGFBR2 Recombinant Protein (His tag)
OverviewProduct Name:Mouse TGFBR2 Recombinant Protein (His tag)Product Code:RPES5784Size:20µgSpecies:MouseExpre