Mouse Frizzled 2/FZD2 Recombinant Protein (RPES0846)

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SKU:
RPES0846
Product Type:
Recombinant Protein
Species:
Mouse

Description

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Mouse Frizzled 2/FZD2 Recombinant Protein

Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.

Product Name:Mouse Frizzled 2/FZD2 Recombinant Protein (RPES0846)
Product Code:RPES0846
Size:10µg
Species:Mouse
Expressed Host:Human Cells
Synonyms:Frizzled-2, Fz-2, mFz2, Fzd2,frizzled (Drosophila) homolog 2
Accession:Q9JIP6
Sequence:Gln29-Leu168
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse frizzled (Drosophila) homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a Fc tag at the C-terminus.
Purity:> 95 % as determined by SDS-PAGE
Mol Mass:42.9 kDa
AP Mol Mass:55-60 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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