Growth Factors & Cytokines Recombinant Proteins
Mouse FGF 8 Recombinant Protein (RPPB0218)
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- SKU:
- RPPB0218
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P37237
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse FGF 8 Recombinant Protein |
| Product Code: | RPPB0218 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | FGF 8 |
| Synonyms: | FGF8B, FGF-8B, FGF8-B, KAL6, HBGF-8, HBGF8, AIGF, HBGF-8, MGC149376, fibroblast growth factor 8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing 5mM Na3PO4 and 50 mM NaCl, pH 7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized FGF 8 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.� |
| Stability: | Lyophilized FGF 8 although stable at room temperature for 3 weeks, should be stored desiccated below -18?C. Upon reconstitution FGF 8 should be stored at 4?C between 2-7 days and for future use below -18?C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGDPFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR |
| Biological Activity: | The activity is determined by its ability to induce proliferation of mouse 3T3 cells and is typically less than 20ng/ml corresponding to a specific activity of 50,000units/mg. |
FGF8 is part of the fibroblast growth factor family. FGF family members have wide mitogenic and cell survival activities, and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.
FGF 8 Mouse�Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 194 amino acids and having a total molecular mass of 22.5kDa.�
| UniProt Protein Function: | FGF8: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6). Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Secreted; CytokineCellular Component: external side of plasma membrane; extracellular spaceMolecular Function: chemoattractant activity; growth factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor bindingBiological Process: adrenocorticotropin hormone secreting cell differentiation; apoptosis; blood vessel remodeling; BMP signaling pathway; cell fate commitment; cell proliferation in forebrain; central nervous system neuron development; determination of left/right symmetry; dorsal/ventral axon guidance; embryonic development ending in birth or egg hatching; embryonic heart tube development; embryonic hindlimb morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain dorsal/ventral pattern formation; forebrain morphogenesis; forebrain neuron development; generation of neurons; gonad development; heart development; heart looping; heart morphogenesis; induction of an organ; inner ear morphogenesis; kidney development; limb morphogenesis; lung development; male genitalia development; MAPKKK cascade; mesodermal cell migration; midbrain-hindbrain boundary development; motor axon guidance; negative regulation of apoptosis; negative regulation of cardiac muscle development; negative regulation of neuron apoptosis; neural plate morphogenesis; otic vesicle formation; pallium development; patterning of blood vessels; pharyngeal system development; positive regulation of cell proliferation; positive regulation of mitosis; positive regulation of organ growth; regulation of odontogenesis of dentine-containing teeth; response to oxidative stress; subpallium development; telencephalon development; thyroid gland development; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P37237 |
| NCBI GenInfo Identifier: | 585131 |
| NCBI Gene ID: | 14179 |
| NCBI Accession: | P37237.1 |
| UniProt Secondary Accession: | P37237 |
| UniProt Related Accession: | P37237 |
| Molecular Weight: | 23,522 Da |
| NCBI Full Name: | Fibroblast growth factor 8 |
| NCBI Synonym Full Names: | fibroblast growth factor 8 |
| NCBI Official Symbol: | Fgf8�� |
| NCBI Official Synonym Symbols: | Aigf; Fgf-8�� |
| NCBI Protein Information: | fibroblast growth factor 8 |
| UniProt Protein Name: | Fibroblast growth factor 8 |
| UniProt Synonym Protein Names: | Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8 |
| Protein Family: | |
| UniProt Gene Name: | Fgf8�� |
| UniProt Entry Name: | FGF8_MOUSE |
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