Chemokines Recombinant Proteins

Mouse Exodus 2 Recombinant Protein (RPPB1132)

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RPPB1132

Description

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Product Name:Mouse Exodus 2 Recombinant Protein
Product Code:RPPB1132
Size:20µg
Species:Mouse
Target:Exodus 2
Synonyms:Small inducible cytokine A21, CCL21, Beta chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC, chemokine (C-C motif) ligand 21, ECL, CKb9, TCA4, SCYA21, MGC34555.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution in water containing 20mM Phosphate buffer and 0.15M NaCl pH-7.4.
Solubility:It is recommended to reconstitute the lyophilized Exodus2 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions
Stability:Lyophilized Exodus-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL21 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by SDS-PAGE & RP-HPLC.
Amino Acid Sequence:SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG
Biological Activity:Determined� by its ability to chemoattract total murine T cell population using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 is expressed predominantly in the lymph nodes and, in contrast to other CC chemokines, is chemotactic for lymphocytes. The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

Exodus-2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 110 amino acids and having a molecular mass of 12kDa. The CCL21 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P84444
NCBI GenInfo Identifier:302488378
NCBI Gene ID:100504362
NCBI Accession:NP_001180596.1
UniProt Secondary Accession:P84444,O09002, O09006, Q3U1J2, Q91V84
UniProt Related Accession:P84444
Molecular Weight:14,558 Da
NCBI Full Name:predicted gene 1987
NCBI Synonym Full Names:predicted gene 1987
NCBI Official Symbol:Gm1987��
NCBI Official Synonym Symbols:100038965��
NCBI Protein Information:predicted gene 1987
UniProt Protein Name:C-C motif chemokine 21a
UniProt Synonym Protein Names:6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4; TCA4
Protein Family:
UniProt Gene Name:Ccl21a��
UniProt Entry Name:
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P84444
Research Area:
Chemokines
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