Mouse EPHB4 Recombinant Protein (RPPB3458)
- SKU:
- RPPB3458
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P54761
Description
| Product Name: | Mouse EPHB4 Recombinant Protein |
| Product Code: | RPPB3458 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | EPHB4 |
| Synonyms: | Ephrin type-B receptor 4 (EC:2.7.10.1), Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Ephb4, Htk, Mdk2, Myk1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | EPHB4 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | LEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLAVEHHHHHH |
Ephrin type-B receptor 4 isoform b (Ephb4) belongs to the Eph receptor tyrosine kinase family which functions in neuronal guidance and mediate venal/arterial separation. EPHB4-mediated forward signaling regulates cellular repulsion and segregation form EFNB2-expressing cells. Furthermore, Ephb4 has a role in postnatal blood vessel remodeling, morphogenesis and permeability and is therefore essential in the context of tumor angiogenesis.
EPHB4 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 532 amino acids (16-539 a.a.) and having a molecular mass of 58.7kDa (Migrates at 50-70kDa on SDS-PAGE under reducing conditions).EPHB4 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EphB4: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; Eph family Cellular Component: integral to plasma membrane Molecular Function:ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity Biological Process: angiogenesis; cell adhesion; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; protein amino acid autophosphorylation; venous blood vessel morphogenesis |
| UniProt Code: | P54761 |
| NCBI GenInfo Identifier: | 341940661 |
| NCBI Gene ID: | 13846 |
| NCBI Accession: | P54761.2 |
| UniProt Secondary Accession: | P54761,Q60627, Q99MR2, |
| UniProt Related Accession: | P54761 |
| Molecular Weight: | 108,848 Da |
| NCBI Full Name: | Ephrin type-B receptor 4 |
| NCBI Synonym Full Names: | Eph receptor B4 |
| NCBI Official Symbol: | Ephb4�� |
| NCBI Official Synonym Symbols: | Htk; MDK2; Myk1; Tyro11; AI042935�� |
| NCBI Protein Information: | ephrin type-B receptor 4 |
| UniProt Protein Name: | Ephrin type-B receptor 4 |
| UniProt Synonym Protein Names: | Developmental kinase 2; mDK-2; Hepatoma transmembrane kinase; Tyrosine kinase MYK-1 |
| Protein Family: | Ephrin type-B receptor |
| UniProt Gene Name: | Ephb4�� |
| UniProt Entry Name: | EPHB4_MOUSE |
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