Mouse ENPP7/NPP-7 Recombinant Protein (RPES1221)
- SKU:
- RPES1221
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse ENPP7/NPP-7 Recombinant Protein
Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.
| Product Name: | Mouse ENPP7/NPP-7 Recombinant Protein (RPES1221) |
| Product Code: | RPES1221 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Alk-SMase,Gm254 |
| Accession: | Q3TIW9 |
| Sequence: | Met 1-Gln 421 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse ENPP7 (Q3TIW9) (Met 1-Gln 421) was expressed, with a polyhistidine tag at the C-terminus. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Mol Mass: | 47 kDa |
| AP Mol Mass: | 60 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 7.6 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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