Mouse EGFR Recombinant Protein (RPES2842)
- SKU:
- RPES2842
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse EGFR Recombinant Protein
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Mouse EGFR Recombinant Protein (RPES2842) |
| Product Code: | RPES2842 |
| Size: | 50µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | 9030024J15Rik,AI552599,Erbb,Errb1,Errp,wa-2,wa2,Wa5 |
| Accession: | Q01279 |
| Sequence: | Met 1-Ser 647 |
| Fusion tag: | C-His |
| Activity: | 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse EGFR-his at 10 µg/mL (100 ?l/well) can bind human EGF-Fc , The EC50 of human EGF-Fc is 60-90 ng/mL.3. Immobilized mouse EGFR-his at 10 µg/mL (100 ?l/well) can bind mouse EGF-Fc, The EC50 of mouse EGF-Fc is 70-100 ng/mL. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of mouse EGFR (Q01279) (Met 1-Ser 647) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 71 kDa |
| AP Mol Mass: | 100 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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