Cytokines Recombinant Proteins

Mouse EBI3 Recombinant Protein (RPPB0159)

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RPPB0159

Description

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Product Name:Mouse EBI3 Recombinant Protein
Product Code:RPPB0159
Size:10µg
Species:Mouse
Target:EBI3
Synonyms:IL-27B, IL27B, IL 27-B, EBI-3, Interleukin-27 beta, IL-27 subunit beta, Epstein-Barr virus-induced gene 3 protein homolog, EBI3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:EBI3 was lyophilized from 10mM Sodium Citrate pH-3.
Solubility:It is recommended to reconstitute the lyophilized EBI3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized EBI3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EBI3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 90% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MALVALSQPR VQCHASRYPV AVDCSWTPLQ APNSTRSTSF IATYRLGVAT QQQSQPCLQR SPQASRCTIP DVHLFSTVPY MLNVTAVHPG GASSSLLAFV AERIIKPDPP EGVRLRTAGQ RLQVLWHPPA SWPFPDIFSL KYRLRYRRRG ASHFRQVGPI EATTFTLRNS KPHAKYCIQV SAQDLTDYGK PSDWSLPGQV ESAPHKP

EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4(+) t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4(+) t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.

EBI3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids and having a molecular mass of 22.9kDa. The Murine EBI3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 17 D|17 29.08 cMMolecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein bindingBiological Process: T cell proliferation
UniProt Protein Details:
NCBI Summary:
UniProt Code:O35228
NCBI GenInfo Identifier:47605771
NCBI Gene ID:50498
NCBI Accession:O35228.1
UniProt Secondary Accession:O35228
UniProt Related Accession:O35228
Molecular Weight:25,353 Da
NCBI Full Name:Interleukin-27 subunit beta
NCBI Synonym Full Names:Epstein-Barr virus induced gene 3
NCBI Official Symbol:Ebi3��
NCBI Official Synonym Symbols:EBI-3; IL-27��
NCBI Protein Information:interleukin-27 subunit beta
UniProt Protein Name:Interleukin-27 subunit beta
UniProt Synonym Protein Names:Epstein-Barr virus-induced gene 3 protein homolog
Protein Family:Interleukin
UniProt Gene Name:Ebi3��
UniProt Entry Name:
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
O35228
Research Area:
Cytokines
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