Enzymes Recombinant Proteins

Mouse Cyclophilin A Recombinant Protein (RPPB1532)

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SKU:
RPPB1532
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P17742
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse Cyclophilin A Recombinant Protein
Product Code:RPPB1532
Size:20µg
Species:Mouse
Target:Cyclophilin A
Synonyms:Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A, SP18, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed, Ppia, 2700098C05 Cphn, CyP-18, CypA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:Cyclophilin A protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMVNPTVF FDITADDEPL GRVSFELFAD KVPKTAENFR ALSTGEKGFG YKGSSFHRII PGFMCQGGDF TRHNGTGGRS IYGEKFEDEN FILKHTGPGI LSMANAGPNT NGSQFFICTA KTEWLDGKHV VFGKVKEGMN IVEAMERFGS RNGKTSKKIT ISDCGQL

PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilin-A is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. Cyclophilin-A can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Cyclophilin A Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 187 amino acids (1-164a.a.) and having a molecular mass of 20.4kDa.Cyclophilin A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
UniProt Protein Details:

Protein type:EC 5.2.1.8; Isomerase; RNA-binding; Cyclophilin

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; membrane; myelin sheath; nucleus

Molecular Function:cyclosporin A binding; isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: neuron differentiation; positive regulation of protein secretion; positive regulation of viral genome replication; protein folding; protein peptidyl-prolyl isomerization; regulation of viral genome replication

UniProt Code:P17742
NCBI GenInfo Identifier:6679439
NCBI Gene ID:268373
NCBI Accession:NP_032933.1
UniProt Secondary Accession:P17742,Q9CWJ5, Q9R137,
UniProt Related Accession:P17742
Molecular Weight:17,971 Da
NCBI Full Name:peptidyl-prolyl cis-trans isomerase A
NCBI Synonym Full Names:peptidylprolyl isomerase A
NCBI Official Symbol:Ppia��
NCBI Official Synonym Symbols:Cphn; CypA; CyP-18; 2700098C05��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase A
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase A
UniProt Synonym Protein Names:Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:Ppia��
UniProt Entry Name:PPIA_MOUSE
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system_update_altDatasheetHuman Cyclophilin A Recombinant Protein Peptidyl-prolyl cis-trans isomerase A; also known as PPIase A; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; PPIA a