Enzymes Recombinant Proteins

Mouse CTSL Recombinant Protein (RPPB1520)

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SKU:
RPPB1520
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P06797
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse CTSL Recombinant Protein
Product Code:RPPB1520
Size:5µg
Species:Mouse
Target:CTSL
Synonyms:Cathepsin L1, Cathepsin L, Major excreted protein, MEP, p39cysteine proteinase.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:CTSLprotein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% asdetermined by SDS-PAGE.
Amino Acid Sequence:TPKFDQTFSAEWHQWKSTHR RLYGTNEEEW RRAIWEKNMR MIQLHNGEYS NGQHGFSMEM NAFGDMTNEE FRQVVNGYRHQKHKKGRLFQ EPLMLKIPKS VDWREKGCVT PVKNQGQCGS CWAFSASGCL EGQMFLKTGK LISLSEQNLVDCSHAQGNQG CNGGLMDFAF QYIKENGGLD SEESYPYEAK DGSCKYRAEF AVANDTGFVD IPQQEKALMKAVATVGPISV AMDASHPSLQ FYSSGIYYEP NCSSKNLDHG VLLVGYGYEG TDSNKNKYWL VKNSWGSEWGMEGYIKIAKD RDNHCGLATA ASYPVVNLEH HHHHH

Cathepsin-L also known as CTSL is a member of the peptidase C1 family. CTSL, is a dimer composed of disulfide-linked heavy and light chains, both formed from a single protein precursor. Furthermore, CTSL is a lysosomal cysteine proteinase which takes a main part in intracellular protein catabolism. CTSL substrates include collagen and elastin, as well as alpha-1 protease inhibitor, which is the most important controlling element of neutrophil elastase activity. CTSL has been implicated in a number of pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Multiple alternatively spliced transcript variants have been found for CTSL.

CTSL Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 325 amino acids (18-334a.a.) and having a molecular mass of 36.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CTSL is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family.
UniProt Protein Details:

Protein type:Secreted; EC 3.4.22.15; Protease; Secreted, signal peptide

Cellular Component: apical part of cell; cytoplasm; cytoplasmic vesicle; external side of plasma membrane; extracellular space; lysosome; microvillus; neuron projection; nucleolus; nucleus; perikaryon; secretory granule; vacuole

Molecular Function:aminopeptidase activity; cysteine-type carboxypeptidase activity; cysteine-type endopeptidase activity; histone binding; kininogen binding; peptide binding; protein binding; protein complex binding

Biological Process: catagen; cell communication; decidualization; hair follicle morphogenesis; protein autoprocessing; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process

NCBI Summary:This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
UniProt Code:P06797
NCBI GenInfo Identifier:115742
NCBI Gene ID:13039
NCBI Accession:P06797.2
UniProt Secondary Accession:P06797,Q91UZ0,
UniProt Related Accession:P06797
Molecular Weight:37,547 Da
NCBI Full Name:Cathepsin L1
NCBI Synonym Full Names:cathepsin L
NCBI Official Symbol:Ctsl��
NCBI Official Synonym Symbols:fs; MEP; nkt; CatL; Ctsl1; 1190035F06Rik��
NCBI Protein Information:cathepsin L1
UniProt Protein Name:Cathepsin L1
UniProt Synonym Protein Names:Cathepsin L; Major excreted protein; MEP
UniProt Gene Name:Ctsl��
UniProt Entry Name:CATL1_MOUSE
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