Immunology Recombinant Proteins
Mouse CTLA4 Recombinant Protein (RPES0398)
- SKU:
- RPES0398
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Immunology
Description
Mouse CTLA4 Recombinant Protein
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
| Product Name: | Mouse CTLA4 Recombinant Protein (RPES0398) |
| Product Code: | RPES0398 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4 |
| Accession: | P09793 |
| Sequence: | Ala37-Asp161 |
| Fusion tag: | C-Fc |
| Activity: | Immobilized Human B7-1-mFc(Cat: PKSH033784) at 10µg/ml(100 ?l/well) can bind Mouse CTLA-4-Fc. The ED50 of Mouse CTLA-4-Fc is 0.02µg/mL. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Cytotoxic T-lymphocyte protein 4 is produced by our Mammalian expression system and the target gene encoding Ala37-Asp161 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 40.4 kDa |
| AP Mol Mass: | 50-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Mouse CTLA4 Recombinant Protein (RPPB0152)
Cytokines Recombinant Proteins
Mouse CTLA4 Recombinant Protein (RPES0378)
Immunology Recombinant Proteins
Mouse CTLA4 Recombinant Protein (RPES0361)
Immunology Recombinant Proteins
Mouse CTLA4/CD152 Recombinant Protein (RPES1637)
