Mouse CES2 Recombinant Protein (RPES1598)
- SKU:
- RPES1598
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
system_update_altDatasheet
Mouse CES2 Recombinant Protein
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
| Product Name: | Mouse CES2 Recombinant Protein (RPES1598) |
| Product Code: | RPES1598 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | ces2A3 |
| Accession: | NP_663578.1 |
| Sequence: | Met 1-Lys 557 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is >90,000 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of mouse CES2 (NP_663578.1) (Met 1-Lys 557) was expressed, with a polyhistidine tag at the C-terminus. |
| Purity: | > 85 % as determined by SDS-PAGE |
| Mol Mass: | 60.4 kDa |
| AP Mol Mass: | 52 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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