Mouse CD8a Monoclonal Antibody (PE/Cyanine7 Conjugated) [53-7.6](AGEL1341)
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](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/12358/16410/mouse-cd8a-monoclonal-antibody-pecyanine7-conjugated-53-7.6agel1341__50314__36511.1706269990.jpg?c=1 "Mouse CD8a Monoclonal Antibody (PE/Cyanine7 Conjugated) [53-7.6](AGEL1341)")
- SKU:
- AGEL1341
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Description
| Antibody Name: | Mouse CD8a Monoclonal Antibody (PE/Cyanine7 Conjugated) |
| Antibody Code: | AGEL1341 |
| Size: | 50µg |
| Clone: | 53-7.6 |
| Synonyms: | T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Applications: | FC |
| Concentration: | 1mg/mL |
| Isotype: | IgG2a,k |
| Conjugation: | PE/Cyanine7 |
| Applications: | FC |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Gene ID: | 12525 |
| Uniprot: | P01731 |
| Background: | CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. |
 | C57BL/6 murine splenocytes are stained with Anti-Mouse CD8a Monoclonal Antibody(PE/Cyanine7 Conjugated)[Used at ?g/106 cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control. |