Mouse CD8a monoclonal antibody (APC) (AGIM0246)

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SKU:
AGIM0246
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
YTS 169.4
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:Mouse CD8a monoclonal antibody (APC)
Product Code:AGIM0246
Size:500 µL
Reactivity:Mouse
Clone:YTS 169.4
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2b
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P01731
UniProt Protein Function:Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
UniProt Code:P01731
NCBI GenInfo Identifier:124487437
NCBI Gene ID:12525
NCBI Accession:NP_001074579.1
UniProt Related Accession:P01731
Molecular Weight:32-36kDa
NCBI Full Name:T-cell surface glycoprotein CD8 alpha chain isoform 1
NCBI Synonym Full Names:CD8 antigen, alpha chain
NCBI Official Symbol:Cd8a  
NCBI Official Synonym Symbols:Ly-2; Ly-B; Ly-35; Lyt-2; BB154331  
NCBI Protein Information:T-cell surface glycoprotein CD8 alpha chain
UniProt Protein Name:T-cell surface glycoprotein CD8 alpha chain
UniProt Synonym Protein Names:T-cell surface glycoprotein Lyt-2; CD_antigen: CD8a
Protein Family:CD81 antigen
UniProt Gene Name:Cd8a  
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