Mouse CD8a Monoclonal Antibody [53.6.7](AGEL0378)

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SKU:
AGEL0378
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
53.6.7
Conjugation:
Unconjugated
Applications:
FC
Applications:
IHC
Applications:
IF

Description

system_update_altDatasheet
Antibody Name:Mouse CD8a Monoclonal Antibody
Antibody Code:AGEL0378
Size:100µg
Clone:53.6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation antigen T8/Leu-2, MAL
Host Species:Rat
Species Reactivity:Mouse
Applications:FC, IHC, IF
Concentration:1mg/mL
Isotype:IgG2a
Conjugation:Unconjugated
Applications:FC, IHC, IF
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300
Storage:Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Gene ID:12525
Uniprot:P01731
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
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