Mouse CD86 monoclonal antibody (APC) (AGIM0560)

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SKU:
AGIM0560
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
GL-1
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:Mouse CD86 monoclonal antibody (APC)
Product Code:AGIM0560
Size:100 µL
Reactivity:Mouse
Clone:GL-1
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2a
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P42081
Background:CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigenpresenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
UniProt Protein Function:CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function:protein binding; coreceptor activity; receptor activity; receptor binding

Biological Process: positive regulation of lymphotoxin A biosynthetic process; negative regulation of T cell anergy; T cell activation; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; response to drug; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response

NCBI Summary:This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
UniProt Code:P42081
NCBI GenInfo Identifier:317373339
NCBI Gene ID:942
NCBI Accession:P42081.2
UniProt Secondary Accession:P42081,Q13655, Q6FHB1, Q6GTS4, Q7M4L5, A0N0P0, B7Z2F3 B7Z702, E7ETN5, E9PC27,
UniProt Related Accession:P42081
Molecular Weight:329
NCBI Full Name:T-lymphocyte activation antigen CD86
NCBI Synonym Full Names:CD86 molecule
NCBI Official Symbol:CD86  
NCBI Official Synonym Symbols:B70; B7-2; B7.2; LAB72; CD28LG2  
NCBI Protein Information:T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
UniProt Protein Name:T-lymphocyte activation antigen CD86
UniProt Synonym Protein Names:Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86
UniProt Gene Name:CD86  
UniProt Entry Name:CD86_HUMAN
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