Mouse CD62L monoclonal antibody (FITC) (AGIM0509)

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AGIM0509

Description

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Product Name:Mouse CD62L monoclonal antibody (FITC)
Product Code:AGIM0509
Size:100 µL
Reactivity:Mouse
Clone:MEL-14
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P18337
Background:CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of most T and B lymphocytes, neutrophils, monocytes, eosinophils and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activationinduced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).
UniProt Protein Function:SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; protease binding; cell adhesion molecule binding; carbohydrate binding; glycolipid binding

Biological Process: regulation of apoptosis; cell adhesion; response to ATP

UniProt Code:P18337
NCBI GenInfo Identifier:126179
NCBI Gene ID:20343
NCBI Accession:P18337.1
UniProt Related Accession:P18337
Molecular Weight:42,288 Da
NCBI Full Name:L-selectin
NCBI Synonym Full Names:selectin, lymphocyte
NCBI Official Symbol:Sell  
NCBI Official Synonym Symbols:Lnhr; CD62L; Ly-22; Lyam1; Ly-m22; Lyam-1; LECAM-1; AI528707; L-selectin  
NCBI Protein Information:L-selectin; LAM-1; LECAM1; lymphocyte antigen 22; lymph node homing receptor; leukocyte adhesion molecule 1; CD62 antigen-like family member L; lymphocyte surface MEL-14 antigen; leukocyte-endothelial cell adhesion molecule 1
UniProt Protein Name:L-selectin
UniProt Synonym Protein Names:CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; Ly-22; Lymphocyte surface MEL-14 antigen; CD_antigen: CD62L
Protein Family:L-selectin
UniProt Gene Name:Sell  
UniProt Entry Name:LYAM1_MOUSE
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Additional Information

Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
MEL-14
Conjugation:
FITC
Applications:
FC
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