Description
system_update_altDatasheet
Product Name: | Mouse CD62L monoclonal antibody (FITC) |
Product Code: | AGIM0509 |
Size: | 100 µL |
Reactivity: | Mouse |
Clone: | MEL-14 |
Applications: | Flow Cytometry |
Conjugate: | FITC |
Isotype: | IgG2a |
Host Species: | Rat |
Storage: | Store at 4°C. Avoid prolonged exposure to light. |
Uniprot: | P18337 |
Background: | CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of most T and B lymphocytes, neutrophils, monocytes, eosinophils and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activationinduced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). |
UniProt Protein Function: | SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; protease binding; cell adhesion molecule binding; carbohydrate binding; glycolipid binding Biological Process: regulation of apoptosis; cell adhesion; response to ATP |
UniProt Code: | P18337 |
NCBI GenInfo Identifier: | 126179 |
NCBI Gene ID: | 20343 |
NCBI Accession: | P18337.1 |
UniProt Related Accession: | P18337 |
Molecular Weight: | 42,288 Da |
NCBI Full Name: | L-selectin |
NCBI Synonym Full Names: | selectin, lymphocyte |
NCBI Official Symbol: | Sell |
NCBI Official Synonym Symbols: | Lnhr; CD62L; Ly-22; Lyam1; Ly-m22; Lyam-1; LECAM-1; AI528707; L-selectin |
NCBI Protein Information: | L-selectin; LAM-1; LECAM1; lymphocyte antigen 22; lymph node homing receptor; leukocyte adhesion molecule 1; CD62 antigen-like family member L; lymphocyte surface MEL-14 antigen; leukocyte-endothelial cell adhesion molecule 1 |
UniProt Protein Name: | L-selectin |
UniProt Synonym Protein Names: | CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; Ly-22; Lymphocyte surface MEL-14 antigen; CD_antigen: CD62L |
Protein Family: | L-selectin |
UniProt Gene Name: | Sell |
UniProt Entry Name: | LYAM1_MOUSE |