](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/11266/15320/mouse-cd49b-monoclonal-antibody-alexa-fluor-488-conjugated-dx5agel0442__68239__50702.1706269425.jpg?c=1?imbypass=on "Mouse CD49b Monoclonal Antibody (Alexa Fluor 488 Conjugated) [DX5](AGEL0442)")
Description
system_update_altDatasheet
| Antibody Name: | Mouse CD49b Monoclonal Antibody (Alexa Fluor 488 Conjugated) |
| Antibody Code: | AGEL0442 |
| Size: | 50 Tests |
| Clone: | DX5 |
| Synonyms: | Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Applications: | FC |
| Concentration: | 5uL |
| Isotype: | IgM |
| Conjugation: | Alexa Fluor 488 |
| Applications: | FC |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| Storage Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Gene ID: | 16398 |
| Uniprot: | Q62469 |
| Background: | DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen. |
 | Mouse bone marrow cells are stained with Anti-Mouse CD49b Monoclonal Antibody(Alexa Fluor 488 Conjugated)(filled gray curve). Unstained bone marrow cells (blank black curve) are used as control. |
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