Immunology Recombinant Proteins
Mouse CD40/TNFRSF5 Recombinant Protein (RPES0345)
- SKU:
- RPES0345
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Immunology
Description
Mouse CD40/TNFRSF5 Recombinant Protein
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
| Product Name: | Mouse CD40/TNFRSF5 Recombinant Protein (RPES0345) |
| Product Code: | RPES0345 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, TNFRSF5,I326936,HIGM1, IGM, IMD3, p50, T-BAM, Tnfrsf5, TRAP |
| Accession: | P27512 |
| Sequence: | Leu20-Arg193 |
| Fusion tag: | C-His |
| Activity: | Immobilized Human CD40L(Cat: PKSH033725) at 5µg/ml(100 ?l/well) can bind Mouse CD40-6His. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse CD40 is produced by our Mammalian expression system and the target gene encoding Leu20-Arg193 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 20.2 kDa |
| AP Mol Mass: | 21-25 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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