Mouse CD279/PD-1 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) [29F.1A12](AGEL1630)

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SKU:
AGEL1630
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
29F.1A12
Conjugation:
PE/Cy5.5

Description

Antibody Name:Mouse CD279/PD-1 Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Antibody Code:AGEL1630
Size:50 Tests
Clone:29F.1A12
Synonyms:PD-1, Programmed Death-1
Host Species:Rat
Species Reactivity:Mouse
Applications:FC
Concentration:5uL
Isotype:IgG2a,k
Conjugation:PE/Cyanine5.5
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Gene ID:18566
Uniprot:Q02242
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Mouse CD19 Monoclonal Antibody (FITC Conjugated)Con-A stimulated C57BL/6 splenocytes (3 days) are stained with Anti-Mouse CD279/PD-1 Monoclonal Antibody(PE/Cyanine5.5 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
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