Mouse CD19 monoclonal antibody (APC) (AGIM0552)

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SKU:
AGIM0552
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
1D3
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:Mouse CD19 monoclonal antibody (APC)
Product Code:AGIM0552
Size:100 µL
Reactivity:Mouse
Clone:1D3
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2a
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P15391
Background:CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
UniProt Protein Function:Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
NCBI Summary:Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
UniProt Code:P15391
NCBI GenInfo Identifier:160332376
NCBI Gene ID:930
NCBI Accession:P15391.6
UniProt Secondary Accession:P15391,Q96S68, Q9BRD6, A0N0P9, F5H635,
UniProt Related Accession:P15391
Molecular Weight:
NCBI Full Name:B-lymphocyte antigen CD19
NCBI Synonym Full Names:CD19 molecule
NCBI Official Symbol:CD19  
NCBI Official Synonym Symbols:B4; CVID3  
NCBI Protein Information:B-lymphocyte antigen CD19
UniProt Protein Name:B-lymphocyte antigen CD19
UniProt Synonym Protein Names:B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19
Protein Family:B-lymphocyte antigen
UniProt Gene Name:CD19  
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