](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/11806/15860/mouse-cd161nk1.1-monoclonal-antibody-af647-conjugated-pk136agel0493__38466__89857.1706269717.jpg?c=1?imbypass=on "Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated) [PK136](AGEL0493)")
Description
| Antibody Name: | Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated) |
| Antibody Code: | AGEL0493 |
| Size: | 50µg |
| Clone: | PK136 |
| Synonyms: | Killer cell lectin-like receptor subfamily B member 1C,Klrb1c,CD161 antigen-like family member C,Ly-55c,CD161/NK1.1,NKR-P1.9,NKR-P1C,NKR-P1 40,CD161c |
| Host Species: | Mouse |
| Species Reactivity: | Mouse |
| Applications: | FC |
| Concentration: | 1mg/mL |
| Isotype: | IgG2a,k |
| Conjugation: | AF647 |
| Applications: | FC |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Gene ID: | 17059 |
| Uniprot: | P27814 |
| Background: | NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. |
 | C57BL/6 murine splenocytes are stained with Anti-Mouse CD161/NK1.1 Monoclonal Antibody(AF647 Conjugated) and Anti-Mouse CD49b Monoclonal Antibody(AF488 Conjugated)[Both antibodies are used at 0.2 ?g/106 cells dilution]. Splenocytes stained withAnti-Mouse CD49b Monoclonal Antibody(AF488 Conjugated)(right) are used as control. |
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/11806/15860/mouse-cd161nk1.1-monoclonal-antibody-af647-conjugated-pk136agel0493__38466__89857.1706269717.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated) [PK136](AGEL0493)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/11797/15851/mouse-cd161nk1.1-monoclonal-antibody-af647-conjugated-pk136agel0483__39359__56780.1706269714.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated) [PK136](AGEL0483)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/11800/15854/mouse-cd161nk1.1-monoclonal-antibody-apc-conjugated-pk136agel0486__22097__34620.1706269715.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (APC Conjugated) [PK136](AGEL0486)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/11805/15859/mouse-cd161nk1.1-monoclonal-antibody-af488-conjugated-pk136agel0492__80867__80374.1706269717.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (AF488 Conjugated) [PK136](AGEL0492)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/11798/15852/mouse-cd161nk1.1-monoclonal-antibody-fitc-conjugated-pk136agel0484__83092__62845.1706269714.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (FITC Conjugated) [PK136](AGEL0484)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/11799/15853/mouse-cd161nk1.1-monoclonal-antibody-pe-conjugated-pk136agel0485__86840__02183.1706269715.jpg?c=1 "Mouse CD161/NK1.1 Monoclonal Antibody (PE Conjugated) [PK136](AGEL0485)")