Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated) [PK136](AGEL0493)

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SKU:
AGEL0493
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
PK136
Conjugation:
AF 647

Description

Antibody Name:Mouse CD161/NK1.1 Monoclonal Antibody (AF647 Conjugated)
Antibody Code:AGEL0493
Size:50µg
Clone:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C,Klrb1c,CD161 antigen-like family member C,Ly-55c,CD161/NK1.1,NKR-P1.9,NKR-P1C,NKR-P1 40,CD161c
Host Species:Mouse
Species Reactivity:Mouse
Applications:FC
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:AF647
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Gene ID:17059
Uniprot:P27814
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.
Mouse CD19 Monoclonal Antibody (FITC Conjugated)C57BL/6 murine splenocytes are stained with Anti-Mouse CD161/NK1.1 Monoclonal Antibody(AF647 Conjugated) and Anti-Mouse CD49b Monoclonal Antibody(AF488 Conjugated)[Both antibodies are used at 0.2 ?g/106 cells dilution]. Splenocytes stained withAnti-Mouse CD49b Monoclonal Antibody(AF488 Conjugated)(right) are used as control.
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