Mouse CD11b monoclonal antibody (APC) (AGIM0551)

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SKU:
AGIM0551
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
M1/70.15
Conjugation:
APC
Applications:
FC

Description

system_update_altDatasheet
Product Name:Mouse CD11b monoclonal antibody (APC)
Product Code:AGIM0551
Size:100 µL
Reactivity:Mouse
Clone:M1/70.15
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2b
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P05555
Background:CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that noncovalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
UniProt Protein Function:Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668).
UniProt Code:P05555
NCBI GenInfo Identifier:124956
NCBI Gene ID:16409
NCBI Accession:P05555.2
UniProt Secondary Accession:P05555,Q8CA73,
UniProt Related Accession:P05555
Molecular Weight:
NCBI Full Name:Integrin alpha-M
NCBI Synonym Full Names:integrin alpha M
NCBI Official Symbol:Itgam  
NCBI Official Synonym Symbols:CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik  
NCBI Protein Information:integrin alpha-M
UniProt Protein Name:Integrin alpha-M
UniProt Synonym Protein Names:CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b
UniProt Gene Name:Itgam  
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