](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/12224/16276/mouse-cd103-monoclonal-antibody-fitc-conjugated-m290agel1153__24551__79255.1706269862.jpg?c=1?imbypass=on "Mouse CD103 Monoclonal Antibody (FITC Conjugated) [M290](AGEL1153)")
Description
| Antibody Name: | Mouse CD103 Monoclonal Antibody (FITC Conjugated) |
| Antibody Code: | AGEL1153 |
| Size: | 50µg |
| Clone: | M290 |
| Synonyms: | Integrin alpha-E,Itgae,Integrin alpha M290,CD103 |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Applications: | FC |
| Concentration: | 1mg/mL |
| Isotype: | IgG2a,k |
| Conjugation: | FITC |
| Applications: | FC |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Gene ID: | 16407 |
| Uniprot: | Q60677 |
| Background: | CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. |
 | C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody(FITC Conjugated)[Used at ?g/106 cells dilution](filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control. |
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